Job Overview

A full-time Post Doc Fellow position is available in the laboratory of Jun-Lin Guan, PhD in the Department of Cancer Biology at the University of Cincinnati College of Medicine. Research in Dr. Guan’s laboratory aims to understand the fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how the disruption of normal signaling pathways lead to diseases such as cancer. Current studies include the analysis of autophagy and non-canonical functions of multiple autophagy genes in breast cancer and neural stem cells, and mTORC1 signaling in vascular and other tumors and its cross-talk with autophagy. We use a variety of genetically engineered mouse models combined with molecular, cellular and functional genomic approaches as well as CRISPR-based genetic screen, single cell transcriptomics, PROTACs, organoids and optogenetics to gain mechanistic insights of complex signaling networks in vivo.

Candidates with a strong background in cell and molecular biology, cancer research, neuroscience, vascular biology and/or immunology are encouraged to apply. Experience in autophagy, cell signaling, vesicle trafficking, single-cell transcriptional and genomic analysis, stem cells, and mouse models of cancer, neurodegenerative or other diseases are ideal.

Essential Functions

• Conduct research experiments in a particular field within the pre-determined research scope and methodology.
• Gather and analyze data and develop new ideas that promote current research.
• Prepare data summaries, reports, manuscripts and presentations of research results.
• Participate/assist in manuscript writing for publication in scientific journals and/or presentation; may assist in grant writing.
• Keep informed of developments in field to maintain and enhance professional expertise.
• Lab maintenance, including equipment maintenance and ordering of supplies, as needed.
• May teach techniques to others, train, and mentor junior research staff.
• Engage in appropriate training and professional development opportunities. 
• Play an active role in seeking career and research advice, both from the faculty supervisor and from other faculty members as well. 
• Perform related duties based on departmental need. This job description can be changed at any time.

Required Education

Doctoral Degree in biological science, chemistry or a related field.

Required Experience

• In-depth knowledge of specialized field, process or discipline.
• May require experience with specialized software programs. 

Additional Qualifications Considered

• Previous experience in protein chemistry, proteomics, gel electrophoresis, western blotting, and especially mass spectrometry.
• Previous cryo-EM experience.
• Strong scientific writing skills and the ability to work independently.

Physical Requirements/Work Environment