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Post Doc Fellow, Cancer Biology

Date: Mar 7, 2021

Location: Cincinnati, OH, US

Company: University of Cincinnati

The University of Cincinnati is a premier, public, urban research university, ranked as one of America’s top 26 public research universities by the National Science Foundation. U.S. News and World Report has ranked UC in the Top Tier of America’s Best Colleges. The College of Medicine is ranked No.40 Medical School for Research. The 2017 Nature index of Life Science for the University of Cincinnati is ranked as 91 out of more than 5000 Institutes worldwide. In the Web of Sciences ESI ranking, all research catalogs related biology and medicine for University of Cincinnati fall into top 1% globally.


The lab of Dr. Chenran Wang in the Department of Cancer Biology currently has two (2) postdoctoral positions available. One postdoctoral position is dedicated to study the roles of microglia in regulating neurogenesis of Alzheimer’s Disease and the other postdoctoral position is to pursue the functions of glial (astrocyte and microglia) autophagy on brain metastasis. The Wang laboratory focuses on the functions and mechanisms of selective autophagy and lipid metabolisms in development and neurogenesis of postnatal neural stem cells. The lab developed novel genetic mouse models to study different autophagy genes in microglia for the maintenance and differentiation of neural stem cells in Alzheimer’s Disease brain. We are also very interested in the roles of selective autophagy in glia (astrocyte and microglia) for the coevolution of microenvironment with brain metastatic cancers from breast, lung, and melanoma. We use a variety of genetically engineered mouse models combined with single cell RNA-seq, single cell tracing, chemogenetics, clarity technique, metabolic/molecular/cellular approaches to gain insights of crosstalk between glia with neural stem cell and metastatic cancers in vivo.  


Please see Nature Metabolism. (https://www.nature.com/articles/s42255-019-0137-5); Journal of Cell Biology. 216: 2581-2596, 2017 (http://jcb.rupress.org/content/216/8/2581); Journal of Cell Biology. 212: 545-560, 2016 (http://jcb.rupress.org/content/212/5/545); and Nature Neuroscience; 16: 532-542, 2013 (http://www.nature.com/neuro/journal/v16/n5/full/nn.3365.html) for a selection of recent studies from our laboratory. 


These positions will support the University’s mission and commitment to excellence and diversity in our students, faculty, staff and all our activities.  Postdoctoral Fellows serve temporary appointments, and work under the supervision of a faculty mentor who is responsible for the Fellow’s fiscal and intellectual activities.  Appointments shall not exceed five (5) years; however, short extensions may be granted when necessary to complete a critical research project.


Primary Duties:

  • Perform and conduct research required by faculty supervisor to a high standard and in accordance with all institutional and federal regulations.
  • Engage in appropriate training and professional development opportunities.
  • May support the development of proposals for research-related funding and grants.
  • Engage in the dissemination of the results of the research as directed by and with the support of associated faculty members.
  • Communicate to project team progress and results of research activities ensuring that relevant information and issues in the implementation of projects/experiments are captured in as comprehensive and timely manner as possible.
  • Play an active role in seeking career and research advice, both from the faculty supervisor and from other faculty members as well.


Minimum Requirements:

  • Ph.D., M.D., or M.D./Ph.D., required.  
  • Requires an in-depth knowledge of neuroscience research, cancer research, cell and molecular biology.
  • Good oral and written communication skills.
  • Ability to work and collaborate effectively with students, faculty and staff from a variety of culturally diverse backgrounds


Preferred Requirements:

  • Experience in neural stem cell, cancer biology, signal transduction, metabolism, autophagy, glia cells, and genetic mouse models.
  • Experience in mouse intracranial injection.


Include with your application a short statement of research interest and the names and contact information of three professional references.


Please direct any questions concerning the position to:  Chenran Wang, Ph.D. Assistant Professor, Department of Cancer Biology, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies Rm 3318, 3125 Eden Avenue Cincinnati, OH  45267-0521. E-mail: wang2cr@ucmail.uc.edu Tel: (513) 558-4816.


The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application you will be asked to include a Contribution to Diversity and Inclusion statement.


As a UC employee, and an employee of an Ohio public institution, if hired you will not contribute to the federal Social Security system, other than contributions to Medicare. Instead, UC employees have the option to contribute to a state retirement plan (OPERS, STRS) or an alternative retirement plan (ARP).


The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / Minority / Female / Disability / Veteran.


REQ: 44064 

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